HTN Initially 5 mg once daily, may be increased to 10 mg once daily after 1 mth of treatment.
Patient w/ strongly activated renin-angiotensin-aldosterone system; patient in whom diuretic cannot be discontinued Initially 2.5 mg.
Patient w/ renal impairment CrCl 30-60 mL/min 2.5 mg per day;
CrCl 15-30 mL/min 2.5 mg every other day;
CrCl <15 mL/min (haemodialysed patient) 2.5 mg on the day of dialysis.
Elderly Initially 2.5 mg once daily, may be progressively increased to 5 mg after 1 mth then to 10 mg if necessary depending on renal function.
Stable CAD Initially 5 mg once daily for 2 wk, then increased to 10 mg once daily depending on renal function.
Elderly 2.5 mg once daily for 1 wk, then 5 mg once daily the next wk, before increasing the dose up to 10 mg once daily depending on renal function.
Symptomatic heart failure Initially 2.5 mg daily, may be increased after 2 wk to 5 mg once daily if tolerated.